수의과대학 수의과대학

연구내용

약용 식물 성분의 항 산화 효과와 암 치료 효과 가능성을 보기 위한 연구( Evaluation of Effects of antioxidative and anti-cancer of medicinal plants )

연구업적

Evaluation of Protective Effects of Houttuynia cordata on H2O2- induced Oxidative DNA damage Using an Alkaline Comet Assay in Human HepG2 cells. 외 다수

논문제외

1. 01Kim, E., Lee, S., Kim, J-S., Yoon, W.D., Lim, D., Hart, A.J., and Hodgson, W.C. (2006) Cardiovascular effects of Nemopilema nomurai (Scyphozoa: Rhizostomeae) jellyfish venom in rats. Toxicology Letters. 167, 205-211.
2. 02Lee, S., Mian, MF., Lee, H-J., Kang, C-B., Kim, J-S., Ryu, SH., Suh, P-G., Kim, E. (2006) Thimerosal induces oxidative stress in HeLa S epithelial cells. Environmental Toxicology and Pharmacology 22, 194199.
3. 03Kim, E., Lee., S., Mian, M.F., Yun, S.U., Song, M., Yi, K-S., Ryu, S.H., Suh, P-G. (2006) Crosstalk between Src and Major Vault Protein in epidermal growth factor-dependent cell signaling. FEBS Journal 273(4), 793-804.
4. 04 Kim, Y.H., Shin, K.J., Lee, T.G., Kim, E., Lee, M.S., Ryu, S.H., Suh, P.G. (2005) G2 arrest and apoptosis by 2-amino-N-quinoline-8-yl-benzenesulfonamide (QBS), a novel cytotoxic compound. Biochemical Pharmacology 69(9),1333-1341.
5. 05Kim, S-H., Shin, K-J., Kim, D., Kim, Y-H., Han, M.S., Lee, T. G., Kim, E., Ryu, S.H. and Suh, P-G. (2003) Luteolin inhibits the nuclear factor-B transcriptional activity in Rat-1 fibroblasts. Biochemical Pharmacology66, 955-963.
6. 06 Kim, E., Chun, H-O., Jung, S-H., Kim, J.H., Lee, J-M., Suh, B-C., Xiang, M.X., and Rhee, C.K. (2003)Improvement of therapeutic index of phosphodiesterase type IV inhibitors as anti-Asthmatics. Bioorganic &Medicinal Chemistry Letters. 13 (14) 2355-2358.
7. 07Han, J.C., Park, S.Y., Hah, B.G., Choi, G.H., Kim, Y.K., Kwon, T.H., Kim, E.K., Lachaal, M., Jung, C.Y., Lee, W. (2003) Cadmium induces impaired glucose tolerance in rat by down-regulating GLUT4 expression in adipocytes. Archives of Biochemistry and Biophysics. 413(2):213-220.
8. 08Han, M.S., Shin, K-J., Kim, Y-H., Kim, S-H., Lee, T., Kim, E., Ryu, S.H., and Suh, P-G. (2003) Thiram and Ziram Stimulate Non-Selective Cation Channel and Induce Apoptosis in PC12 Cells. Neurotoxicology. 24 (3) 425-434.
9. 09Xin, Z., Kim, E., Lin, C., Liu, W., Tian, L., Yuan, Y., Fu, J. (2003) Effects of icariin on cGMP-specific PDE5 and cAMP-specific PDE4 activities. Asian Journal of Andrology 5 (1), 15-18.
10. 10Kim, E., Kim, J.H., Kim, H.S., Ryu, S.H. and Suh, P-G. (2002) Thimerosal stimulates focal adhesion kinase and cytoskeletal changes by redox modulation. Biochimica et Biophysica Acta 1593, 9-15.

논문-국내

1. 01Hah, D.S., Heo, J.H., Lee, K.C., Cho, M.H., Kim, K.H., Kim, C.H., Lue, J.D., Lee, S.H., Kim, G.S., Kim, E., Kim, J.S. (2006) Assessment of DNA damage using an Alkaline Single Cell Gel Electrophoresis (SCGE) Comet assay and toxic effects in chickens by T-2 toxin treatment. Journal of Toxicology and Public Health 22(2), 75-85.
2. 02 Cho, Y-H., Jung, W-C., Shin, Y-W., Kim, K-W., Ha, J-Y., Heo, S-H., Kim, E., Chung, H-S., Kang, S-J., Choi, Y-J., Kim, S., Lee, H-J. (2006) Muscle tissue distribution level of Ampicillin in Olive flounder (Paralichthys olivaceus), Rockfish (Sebastes schlegeli), and Red sea bream (Pagrus major) following oral administration. Journal of Veterinary Clinics 23(2), 164-168.
3. 03 Lee, S., Al Munawir, Kim, E. (2006) Current methodological review of endocrine disruptor research. Trends in Agriculture &Life Sciences (TALS) 4(2), 79-86.
4. 04 Seo, J-L., Heo, J-H., Jung, M-H., Cho, M-H., Lee, K-C., Kim, K-H., Hah, D-S., Ryu, J-D., Kim, C-H., Kim, G-S., Kim, E., Kim, J-S. (2005) Effects of dietary Gleditschia addition on biochemical composition of pork loin. Korean Journal of Veterinary Research 45(4), 527-536.
5. 05Hah, D-S., Kim, C-H., Kim, G-S., Kim, E., Kim, J-S. (2005) Antioxidative effects of traditional medicinal plants on lipid peroxidation. Korean Journal of Veterinary Research 45(3), 341-350.
6. 06 Cho, Y-H., Kim, E., Lim, Y-Y., Kim, G-S., Lee, H-J. (2005) The micronucleus test of Clean Natural with mice. Korean Journal of Environmental Health 31(5), 411-414.
7. 07 Chun, M-S., Han, S-W., Cho, Y-H., Lim, Y-Y., Kim, E., Lee, H-J. (2005) Bacterial reverse mutation test of Clean Natural using Salmonella typhimurium. Journal of Food Hygiene and Safety 20(3), 175-178.
8. 08Kim, E., Kim, J-Y., Lee, H-J. (2005) Four-week repeat oral toxicity study of Clean Natural in Sprague-Dawley rats. Journal of Toxicology and Public Health 21(3), 263-269.
9. 09Heo, J-H., Jung, M-H., Kim, K-H., Cho, M-H., Lee, K-C., Seo, J-L., Kim, C-H., Hah, D-S., Ryu, J-D., Kim, G-S., Kim, E-G. and Kim, J-S. (2004) A Survay of Chicken Coccidiosis in Slaughtered Chickens. Journal of Veterinary Clinics 21(2), 161-167.
10. 10 하대식, 김영훈, 박정웅, 박재갑, 김충희, 류재두, 정명호, 허정호, 서종립, 조명희, 이국천, 김곤섭, 김의경, 김종수. (2004) 경남지역 야생들쥐에서 Orientia tsutsugamushi 에 대한 항체 조사 및 PCR에 의한 검색. 대한수의학회지 44(2), 241-249.
11. 11Kim, H.S., Song, M., Kim, E., Ryu, S.H. and Suh, P-G. (2003) Dexamethasone differentiates NG108-15 cells through cyclooxygenase1 induction. Experimental and Molecular Medicine35(3), 203-210.
12. 12Kim, E., Park, J.M. (2003) Identification of Novel Target Proteins of cyclic GMP Signaling Pathways Using Chemical Proteomics. Journal of Biochemistry and Molecular Biology.36 (3) 299-304.
13. 13Kim, E., Park, J.B., Ha, S.H., Ryu, S.H., and Suh, P-G. (2002) Carbamoyl-phosphate synthetase 2 is identified as a novel target protein of methotrexate from chemical proteomics. Environmental Mutagens and Carcinogens 22 (4), 236-242.
14. 14Kim, E., Ryu, S.H., and Suh, P-G. (2002) Thimerosal generates superoxide anion by activating NADPH oxidase:a mechanism of thimerosal-induced calcium release. Environmental Mutagens and Carcinogens 22 (4), 229-235.

학술발표

1. 01 Al Munawir, Lee, S., Park, K., Yoon, T-J., Kim, J-S., Kim, E. (2006. 11) Fresh garlic induces apoptosis and cell cycle arrest in intestinal epithelial cells. The 2006 Annual Meeting of the Korean Society of Environmental Mutagens and Carcinogens/ The Korean Society of Toxicology, Autumn Symposium, Seoul, Korea. Poster presentation.
2. 02 Lee, S., Al Munawir, Kim, E. (2006. 09) Focal adhesion kinase is an early apoptoticmarker in oxidative stress-induced apoptosis. The 2006 Annual Meeting of the Korean Society of Veterinary Science, Tongyoung, Korea. Oral presentation.
3. 03Lee, S., Al Munawir, Kim, J-S., Yoon, W.D., Lim, D., Hart, A.J., Hodgson, W.C. Kim, E. (2006. 09) Inhibitory effects of Nemopilema nomurai jellyfish venom in chick biventer cervicis muscle. The 2006 Annual Meeting of the Korean Society of Veterinary Science, Tongyoung, Korea. Poster presentation.
4. 04Kim, E., Lee, S., Kim, J-S., Yoon, W.D., Lim, D., Hart, A.J., Hodgson. W.C. (2006. 10) Cardiovascular effects of Nemopilema nomurai (Scyphozoa: Rhizostomeae) jellyfish venom in rats. The 15th annual meeting of The North Pacific Marine Science Organization (PICES), Yokohama, Japan. Poster presentation.
5. 05Lee, S., Kim, J-S., Kim, E. (2006. 05) Pharmacological Characterization of Nemopilema nomurai(Scyphozoa: Rhizostomeae) venom. The 2006Annual Meeting of the Korean Societyof Environmental Mutagens and Carcinogens/ The Korean Society of Toxicology, Spring Symposium, Daegue, Korea. Poster presentation.
6. 06 Lee, S., Lee, H-J, Kang, C-B., Kim, J-S., Kim, E., Mian, M.F., Ryu, S.H., Suh, P-G. (2005) Thimerosal Induces Oxidative Stress in HeLa S Epithelial Cells. The 2005 Annual Meeting of the Korean Society of Veterinary Science, Jeju, Korea. Poster presentation.
7. 07Hah, D-S., Kim, C-H., Kim, G-S., Kim, E., Kim, J-S. (2005) Antioxidative effects of traditional medicinal plants on lipid peroxidation. The 2005 Annual Meeting of theKorean Society of Veterinary Science. Poster presentation.
8. 08Kim, E., Park, J.M., Mian, M.F., Lee, H.Y., Ryu, S.H., Suh, P-G. (2002) Chemical Proteomics for Deciphering Cyclic Nucleotide Signaling Pathways. The 59thAnnual Fall Meeting of The Biochemical Society of The Republic of Korea. P190.
9. 09Kim, E. (2002) Chemical Proteomics for the Identification of Target Molecules of a Chemical - A Gold Mine or a Coal Mine. The 1st Korea-Japan Conference on Signal Transduction. P35.
10. 10Kim, E., Kim, J.H., Ryu, S.H., and Suh, P-G. (2001) Thimerosal Induce Focal Adhesion Kinase(FAK)- Cleavage and Apoptosis in Hela S Cells. The 41st Annual Meeting of The American Society for Cell Biology.
11. 11Kim, E., Park, J.B., Ha, S.H., Kang, S., Ryu, S.H.,and Suh, P-G. (2001) Chemical GenomicsApproach Bring New Methodology in Identification of Novel Target Proteins of a Chemical. Korea Society of Biochemistry and Molecular Biology.
12. 12Xin, Z.C., Tian, Z.J., Kim, E., Guo, Y.L. (2000) Effect of Icariin and Papaverine on the Activity of Phosphodiesterase V Isolated from Human Blood Platelets. The 5th Asian Uorology Meeting.
13. 13Kim, S.H., Nam, G., Kim, J-H., Shin, J-H.,Yoon, C.M., Kim, E., Rhee, C.K. (2000) The New Pyrimidopyrimidine Derivatives as a PDE IV Inhibitor. The American Pharmaceutical Association .

교수님소개

학력 사항

• 서울대학교 수의학과 (수의학 학사)
• 서울대학교 대학원 수의학과 수의약리학 전공(수의학 석사)
• University of California, Davis 약리학·독성학 전공 (이학 박사)

경력 사항

• Yale University. Postdoctoral Fellow
• Yale University. Postdoctoral Associate
• Yale University. Associate Research Scientist
• CJ(주) 종합기술원 신약개발 총괄
• CJ(주) 종합기술원 Senior Researcher
• 포항공과대학교 연구교수
• 경상대학교 조교수

가입학회

• 미국세포생물학회 정회원
• 미국약리학회 정회원
• 한국독성학회 정회원
• 대한수의학회 정회원

주요연구분야

• 천연물 약리 독성학 (Natural Toxicants)
• 환경독성학 (Environmental Toxicology)
• 신호전달 약리 독성학 (Signal Transduction in Pharmacology/ Toxicology)
• 약리 독성 유전체학 (Pharmacogenomics/ Toxicogenomics)