수의과대학 수의과대학

연구내용

• Genomic and Proteomic Profiling of Cancer Stem Cells in Patients
• Generating Stem cell-based Post-implantation Embryo-like Structure
• Providing Three-dimensional Early Developmental Model of Neuromuscular System
• Developing Novel Biomaterials to Overcome the Limitations of Conventional Tissue Regeneration
• Developing Intractable Disease Models and Modulating their Micro-environment

교수님소개

학력 사항

• 충북대학교 수의과대학 수의학과(수의학사)
• 충북대학교 대학원 수의학과(수의학석사)
• 충북대학교 대학원 수의학과(수의학박사)

경력 사항

• 경상국립대학교 수의과대학 조교수 (현재)

• 한국동물생명공학회 학술위원 (현재)

• 충북대학교 수의방역대학원 초빙부교수

• 미국 Emory University School of Medicine, Atlanta, Postdoctoral Fellow

• 충북대학교 줄기세포·재생의학연구소 박사후연구원 및 전임연구원

• 미국 Johns Hopkins University School of Medicine, Baltimore, Visiting scholar

• 충북대학교 수의과대학 시간강사

   제주대학교 수의과대학 시간강사

주요 연구업적(논문 등)

• Kim E, Zhang S, Wu F, Zhu C, Allen J and Choo HJ. 2022. The role of FAPs for satellite cell activation and muscle homeostasis in pharyngeal muscles. Frontiers in Cell and Developmental Biology. (In revision)

• Kim E, Cai L and Hyun SH. 2021. Effects of Stem Cell Factor (SCF)/c-Kit Signaling on In Vitro Maturation of Porcine Oocytes and Subsequent Developmental Competence After Fertilization. Frontiers in Veterinary Science. 8:1139.

• Choi H, Lee J, Yoon JD, Hwang SU, Cai L, Kim M, Kim G, Oh D, Kim E* and Hyun SH*. 2021. The effect of copper supplementation on in vitro maturation of porcine cumulus-oocyte complexes and subsequent developmental competence after parthenogenetic activation. Theriogenology. 164(1): 84-92. *Co-corresponding authors.

• Hwang SU, Yoon JD, Kim M, Cai L, Choi H, Oh D, Kim E*, and Hyun SH*. 2021. R‐Spondin 2 and WNT/CTNNB1 Signaling Pathways are Required for Porcine Follicle Development and In Vitro Maturation. Animals. 2021. 11: 109. *Co-corresponding authors

• Hwang SU, Eun K, Kim M, Yoon J, Cai L, Choi H, Oh D, Lee G, Kim H, Kim E*, and Hyun SH*. 2021. Establishment of 3d neuro-organoids derived from pig embryonic stem-like cells. International Journal of Molecular Sciences. 2021. 22(5): 1-16 *Co-corresponding authors

• Kim E, Wu F, Wu X and Choo HJ. 2020. Generation of craniofacial myogenic progenitor cells from human induced pluripotent stem cells for skeletal muscle tissue regeneration. Biomaterials. 248:119995.

• Kim E, Kim M, So K, Park YS, Woo CG, and Hyun SH. 2020. Characterization and comparison of genomic profiles between primary cancer cell lines and parent atypical meningioma tumors. Cancer Cell International. 20:345.

• Kim M, Hwang SU, Yoon JD, Jeong YW, Kim E*, and Hyun SH*. 2020. Optimized Approaches for the Induction of Putative Canine Induced Pluripotent Stem Cells from Old Fibroblasts Using Synthetic RNAs. Animals. 10:1848, *Co-corresponding authors.

• Kim E, Kim M, Hwang SU, Kim J, Lee G, Park YS and Hyun SH. 2019. Neural induction of porcine induced pluripotent stem cells and further differentiation using glioblastoma cultured medium. Journal of Cellular and Molecular Medicine. 23(3), 2052-2063.

• Kim E, Hwang SU, Yoo H, Yoon JD, Kim H, Lee G, and Hyun SH. 2018. Isolation and characterization of GFAP-positive porcine neural stem/progenitor cells derived from a GFAP-CreERT2 transgenic piglet. BMC Veterinary Research. 14(1): 331.

• Kim E and Hyun SH. 2016. Apoptosis in porcine pluripotent cells: From ICM to iPSCs. International Journal of Molecular Sciences. 17: 1533.

• Kim E*, Zheng Z*, Jeon Y, Jin YX, Hwang SU, Cai L, Lee CK, Kim NH and Hyun SH. 2016. An Improved System for Generation of Diploid Cloned Porcine Embryos Using Induced Pluripotent Stem Cells Synchronized to Metaphase. PLoS ONE. 11(7): e016028. *Contributed equally.

• Kim E, Hwang SU, Yoo H, Yoon JD, Jeon Y, Kim H, Jeung EB, Lee CK and Hyun SH. 2016. Putative embryonic stem cells derived from porcine cloned blastocysts using induced pluripotent stem cells as donors. Theriogenology. 85(1): 601-616.

• Kim E, Jeon Y, Kim DY, Lee E and Hyun SH. 2015. Antioxidative effect of carboxyethylgermanium sesquioxide (Ge-132) on IVM of porcine oocytes and subsequent embryonic development after parthenogenetic activation and IVF. Theriogenology. 84(2)226-236.

• Cheong SA*, Kim E*, Kwak SS, Jeon Y and Hyun SH. 2015. Improvement in the blastocyst quality and efficiency of putative embryonic stem cell line derivation from porcine embryos produced in vitro using a novel culturing system. Mol. Med. Rep. 12(2): 2140-2148. *Contributed equally.

• Kim E*, Lee SH* and Hyun SH. 2014. Toxicity evaluation of ethanol treatment during in vitro maturation of porcine oocytes and subsequent embryonic development following parthenogenetic activation and in vitro fertilization. Int.J. Mol. Med. 5;34(5)1372-1380. *Contributed equally.

• Kim E and Hyun SH. 2014. Comparative analysis of various donor cell types for somatic cell nuclear transfer and its association with apoptosis and senescence. Mol. Med. Rep. 9 (1): 63 -68.

• Kim E, Cheong SA, Yoon J, Jeon Y and Hyun SH. 2013. Optimal Derivation Timing for Establishment of Pocine Embryonic Stem Cells. J. Emb. Trans. 28 (1): 1-6.

• Oh D, Lee J, Kim E, Hwang SU, Yoon JD, Cai L, Kim M, Kim G, Choi H, and Hyun SH. 2021. Effect of Interleukin‐7 on In Vitro Maturation of Porcine Cumulus‐Oocyte Complexes and Subsequent Developmental Potential after Parthenogenetic Activation. Animals. 11:741.

• Lee J, Kim E, Hwang SU, Cai L, Kim M, Choi H, Oh D, Lee E and Hyun SH. 2021. Effect of D-Glucuronic Acid and N-acetyl-D-Glucosamine Treatment during In Vitro Maturation on Embryonic Development after Parthenogenesis and Somatic Cell Nuclear Transfer in Pigs. Animals. 11:1034.

• Hwang SU, Kim KJ, Kim E, Yoon J, Park KM, Jin M, Han Y, Kim M, Lee G, and Hyun SH. 2018. Lysophosphatidic acid increases in vitro maturation efficiency via uPA uPAR signaling pathway in cumulus cells. Theriogenology. 113: 197-207.

• Yoon J, Hwang SU, Kim E, Jin M, Kim S, and Hyun SH. 2017. GDF8 activates p38 MAPK signaling during porcine oocyte maturation in vitro. Theriogenology. 101: 123-134.

• Jeon Y, Yoon J, Cai L, Hwang SU, Kim E, Lee E, Jeung EB, Hyun SH and Hwang WS. 2016. Zinc supplementation during in vitro maturation increases the production efficiency of cloned pigs. Journal of Reproduction and Development. 62(6): 635-638.

• Yoo HJ, Kim E, Hwang SU, Yoon J, Jeon Y, Park KM, Kim KJ, Jin M and Hyun SH. 2016. Ultrastructural comparison of porcine putative embryonic stem cells derived by in vitro fertilization and somatic cell nuclear transfer. Journal of Reproduction and Development. 62(2): 177-185.

• Jeon Y, Yoon J, Hwang SU, Cai L, Kim E, Lee E, Jeung EB and Hyun SH. 2015. Effect of zinc on in vitro development of porcine embryos. Theriogenology. 84(4)531 -537.

• Cai L, Jeon Y, Yoon J, Hwang SU, Kim E, Park KM, Kim KJ, Jin M, Lee E, Kim H, Jeung EB and Hyun SH. 2015. The effects of human recombinant granulocyte-colony stimulating factor treatment during in vitro maturation of porcine oocyte on subsequent embryonic development. Theriogenology. 84(7) 1075– 1087.

• Jeon Y, Yoon J, Cai L, Hwang SU, Kim E, Zheng Z, Jeung EB, Lee E and Hyun SH. 2015. Zinc deficiency during in vitro maturation of porcine oocytes causes meiotic block and developmental failure. Mol. Med. Rep. 12(4) 5973 -5982.

• Yoon J, Jeon Y, Cai L, Hwang SU, Kim E, Lee E, Kim DY and Hyun SH. 2015. Effects of coculture with cumulusderived somatic cells on in vitro maturation of porcine oocytes. Theriogenology. 83(2) 294-305.

• Hwang SU, Jeon Y, Yoon J, Cai L, Kim E, Yoo H, Kim KJ, Park KM, Jin M, Kim H and Hyun SH. 2015. Effect of ganglioside GT1b on the in vitro maturation of porcine oocytes and embryonic development. Journal of Reproduction and Development. 61(6) 549-557.

• Jeon Y, Yoon J, Cai L, Hwang SU, Kim E, Zheng Z, Lee E, Kim DY, and Hyun SH. 2014. Supplementation of zinc on oocyte in vitro maturation improves preimplatation embryonic development in pigs. Theriogenology. 82(6)866-874.

• Yoon J, Kim E, Hwang SU, Cai L and Hyun SH. 2014. Effect of Co-Culture with Various Somatic Cells during In Vitro Maturation of Immature Oocytes. J. Emb. Trans. 29(1)1-5