수의과대학 수의과대학

연구내용

• 실험동물 이용 질환모델 개발 및 표현형 분석 시스템 개발
• 비알콜성 간질환 및 알콜성 간질환 모델의 비교의학적 분석 기법 개발
• 마약, 알콜 등 중독질환 동물 모델 개발 및 기전 연구
• 중대동물(개, 미니돼지, 영장류 등) 이용 질환 모델 개발 및 신약 효능평가 기술 개발
• 천연물 유래 신약후보물질 효능·안전성 평가 시스템 개발

교수님소개

학력 사항

• 경상대학교 일반대학원 수의과대학(수의학 박사)
• 경상대학교 일반대학원 수의과대학(수의학 석사)
• 경상대학교 수의과대학(수의학사)

경력 사항

• 한국생명공학연구원 국가영장류센터장
• 한국생명공학연구원 선임연구원
• 한국원자력연구원 첨단방사선연구소 박사후연구원(Post-doc)
• 한국원자력의학원 방사선의학연구소 박사후연구원(Post-doc)

주요연구업적(논문 등)

• Ham O, Jin YB, Kim J, Lee MO. Blood vessel formation in cerebral organoids formed from human embryonic stem cells. Biochem Biophys Res Commun. 2020 Jan 1;521(1):84-90.
• Lee SH, Park YH, Jin YB, Kim SU, Hur JK. CRISPR Diagnosis and Therapeutics with Single Base Pair Precision. Trends Mol Med. 2020 Mar;26(3):337-350.
• Choi MR, Han JS, Chai YG, Jin YB, Lee SR, Kim DJ. Gene expression profiling in the hippocampus of adolescent rats after chronic alcohol administration. Basic Clin Pharmacol Toxicol. 2020 Apr;126(4):389-398.
• Seo J, Yeo HG, Park J, Won J, Kim K, Jin YB, Koo BS, Lim KS, Jeong KJ, Kang P, Lee HY, Son HC, Baek SH, Jeon CY, Song BS, Huh JW, Lee DS, Lee SR, Kim SU, Lee Y. A pilot study on assessment of locomotor behavior using a video tracking system in minipigs. Exp Anim. 2020 Jan 29;69(1):62-69.
• Kim TS, Jin YB, Kim YS, Kim S, Kim JK, Lee HM, Suh HW, Choe JH, Kim YJ, Koo BS, Kim HN, Jung M, Lee SH, Kim DK, Chung C, Son JW, Min JJ, Kim JM, Deng CX, Kim HS, Lee SR, Jo EK. SIRT3 promotes antimycobacterial defenses by coordinating mitochondrial and autophagic functions. Autophagy. 2019 Aug;15(8):1356-1375.
• Koo BS, Hwang EH, Kim G, Oh H, Son Y, Lee D, Lim KS, Kang P, Lee S, Lee HY, Jeong KJ, Lee Y, Baek SH, Jeon CY, Park SJ, Kim YH, Huh JW, Jin YB, Kim SU, Lee SR, Hong JJ. Evaluation of fecal microbiomes associated with obesity in captive cynomolgus monkeys (Macaca fascicularis). J Vet Sci. 2019 May;20(3):e19.
• Choi SA, An JH, Lee SH, Lee GH, Yang HJ, Jeong PS, Cha JJ, Lee S, Park YH, Song BS, Sim BW, Kim YH, Kim JS, Jin YB, Huh JW, Lee SR, Lee JH, Kim SU. Comparative Evaluation of Hormones and Hormone-Like Molecule in Lineage Specification of Human Induced Pluripotent Stem Cells. Int J Stem Cells. 2019 Jul 31;12(2):240-250.
• Cho HM, Park SJ, Choe SH, Lee JR, Kim SU, Jin YB, Kim JS, Lee SR, Kim YH, Huh JW. Cooperative evolution of two different TEs results in lineage-specific novel transcripts in the BLOC1S2 gene. BMC Evol Biol. 2019 Oct 30;19(1):196.
• Yoon SB, Park YH, Choi SA, Yang HJ, Jeong PS, Cha JJ, Lee S, Lee SH, Lee JH, Sim BW, Koo BS, Park SJ, Lee Y, Kim YH, Hong JJ, Kim JS, Jin YB, Huh JW, Lee SR, Song BS, Kim SU. Real-time PCR quantification of spliced X-box binding protein 1 (XBP1) using a universal primer method. PLoS One. 2019 Jul 22;14(7):e0219978.
• Park J, Seo J, Won J, Yeo HG, Ahn YJ, Kim K, Jin YB, Koo BS, Lim KS, Jeong KJ, Kang P, Lee HY, Baek SH, Jeon CY, Hong JJ, Huh JW, Kim YH, Park SJ, Kim SU, Lee DS, Lee SR, Lee Y. Abnormal Mitochondria in a Non-human Primate Model of MPTP-induced Parkinson's Disease: Drp1 and CDK5/p25 Signaling. Exp Neurobiol. 2019 Jun;28(3):414-424.
• Yeo HG, Hong JJ, Lee Y, Yi KS, Jeon CY, Park J, Won J, Seo J, Ahn YJ, Kim K, Baek SH, Hwang EH, Kim G, Jin YB, Jeong KJ, Koo BS, Kang P, Lim KS, Kim SU, Huh JW, Kim YH, Son Y, Kim JS, Choi CH, Cha SH, Lee SR. Increased CD68/TGFβ Co-expressing Microglia/ Macrophages after Transient Middle Cerebral Artery Occlusion in Rhesus Monkeys. Exp Neurobiol. 2019 Aug 31;28(4):458-473
• Seo J, Lee Y, Kim BS, Park J, Yang S, Yoon HJ, Yoo J, Park HS, Hong JJ, Koo BS, Baek SH, Jeon CY, Huh JW, Kim YH, Park SJ, Won J, Ahn YJ, Kim K, Jeong KJ, Kang P, Lee DS, Lim SM, Jin YB, Lee SR. A non-human primate model for stable chronic Parkinson's disease induced by MPTP administration based on individual behavioral quantification. J Neurosci Methods. 2019 Jan 1;311:277-287.
• Jeong PS, Yoon SB, Lee MH, Son HC, Lee HY, Lee S, Koo BS, Jeong KJ, Lee JH, Jin YB, Song BS, Kim JS, Kim SU, Koo DB, Sim BW. Embryo aggregation regulates in vitro stress conditions to promote developmental competence in pigs. PeerJ. 2019 Dec 13;7:e8143.
• Cho HM, Park SJ, Choe SH, Lee JR, Kim SU, Jin YB, Kim JS, Lee SR, Kim YH, Huh JW. Cooperative evolution of two different TEs results in lineage-specific novel transcripts in the BLOC1S2 gene. BMC Evol Biol. 2019 Oct 30;19(1):196.
• Jo Y, Hwang SG, Jin YB, Sung J, Jeong YK, Baek JH, Cho JM, Kim EH, Yoon M. Selective toxicity of tumor treating fields to melanoma: an in vitro and in vivo study. Cell Death Discov. 2018 Oct 3;4:46.
• Song BS, Kim Y, Jin YB, Kang IJ, Kim KS, Park JH, Kim JK, Park HY, Jeong SH. Toxicological evaluation of 2-dodecylcyclobutanone, a unique radiolytic compound of palmitic acid. Food Chem Toxicol. 2018 Nov;121:639-647.
• In HJ, Lim H, Lee JA, Lee SR, Jin YB, Jeong KJ, Hyeon JY, Yoo JS, Lee JW, Choi YK, Lee SW. Enhanced neutralizing antibody response induced by inactivated enterovirus 71 in cynomolgus monkeys. PLoS One. 2018 Oct 2;13(10):e0202552.
• Han SK, Lee Y, Hong JJ, Yeo HG, Seo J, Jeon CY, Jeong KJ, Jin YB, Kang P, Lee S, Shin CS, Kim YE, Chun KJ, Chang KT, Lee SR. In vivo study of paraspinal muscle weakness using botulinum toxin in one primate model. Clin Biomech (Bristol, Avon). 2018 Mar;53:1-6.
• Choi MR, Chun JW, Kwak SM, Bang SH, Jin YB, Lee Y, Kim HN, Chang KT, Chai YG, Lee SR, Kim DJ. Effects of acute and chronic methamphetamine administration on cynomolgus monkey hippocampus structure and cellular transcriptome. Toxicol Appl Pharmacol. 2018 Sep 15;355:68-79.
• Song BS, Jeong PS, Lee JH, Lee MH, Yang HJ, Choi SA, Lee HY, Yoon SB, Park YH, Jeong KJ, Kim YH, Jin YB, Kim JS, Sim BW, Huh JW, Lee SR, Koo DB, Chang KT, Kim SU. The effects of kinase modulation on in vitro maturation according to different cumulus-oocyte complex morphologies. PLoS One. 2018 Oct 11;13(10):e0205495.