수의과대학 수의과대학

연구내용

• 염증성대장염의 발병 및 치료 연구
• 대장암의 발병 기전 및 바이오 마커 탐색 연구
• 염증 및 대장암의 상관관계 규명 및 바이오 마커를 이용한 치료기술 개발
• 비만의 발병 기전 및 장과의 상관관계 규명 및 마이크로바이옴 연구
• 피부질환 연구

교수 소개

학력 사항

• University of South Carolina, Post-doc fellow
• 울산과학기술원(UNIST), Post-doc fellow
• 한국한의학연구원 (KIOM), 선임연구원

주요 연구업적(논문 등)

• Do HJ, Hwang YJ, Yang HJ, Park KI. Effect of Rhus verniciflua Extract on IgE-Antigen-Mediated Allergic Reaction in Rat Basophilic Leukemic RBL-2H3 Mast Cells and Passive Cutaneous Anaphylaxis in Mice. Evid Based ComplementAlternat Med. 2019 Oct 9;2019:6497691.
• Kim KY, Oh TW, Yang HJ, Kim YW, Ma JY, Park KI. Ethanol extract of Chrysanthemum zawadskii Herbich induces autophagy and apoptosis in mouse colon cancer cells through the regulation of reactive oxygen species. BMC ComplementAltern Med. 2019 Oct 21;19(1):274.
• Lee EH, Park KI, Kim KY, Lee JH, Jang EJ, Ku SK, Kim SC, Suk HY, Park JY, Baek SY, Kim YW. Liquiritigenin inhibits hepatic fibrogenesis and TGF-β1/Smad with Hippo/YAP signal. Phytomedicine. 2019 Sep;62:152780.
• Kang DS, Yang YR, Lee C, Park B, Park KI, Seo JK, Seo YK, Cho H, Cocco L, Suh PG. Netrin-1/DCC-mediated PLCγ1 activation is required for axon guidance and brain structure development. EMBO Rep. 2019 May;20(5).
• Kim K, Park KI. A Review of Antiplatelet Activity of Traditional Medicinal Herbs on Integrative Medicine Studies. Evid Based Complement Alternat Med. 2019 Jan 3;2019:7125162.
• Yoo JM, Park KI, Yang JH, Cho WK, Lee B, Ma JY. Anti-allergic actions of F-PASA, a novel herbal cocktail, in IgE/antigen-mediated allergic responses in RBL-2H3 cells and passive cutaneous anaphylaxis in mice. Phytomedicine. 2019Mar 1;55:229-237.
• Lee MR, Yang HJ, Park KI, Ma JY. Lycopus lucidus Turcz. ex Benth. Attenuates free fatty acid-induced steatosis in HepG2 cells and non-alcoholic fatty liver disease in high-fat diet-induced obese mice. Phytomedicine. 2019 Mar1;55:14-22.
• Yoo JM, Park KI, Ma JY. Anticolitic Effect of Viscum coloratum through Suppression of Mast Cell Activation. Am J Chin Med. 2019;47(1):203-221.
• Kim KY, Oh TW, Do HJ, Yang JH, Yang IJ, Jeon YH, Go YH, Ahn SC, Ma JY, Park KI. Acer palmatum thumb. Ethanol Extract Alleviates Interleukin-6-Induced Barrier Dysfunction and Dextran Sodium Sulfate-Induced Colitis by ImprovingIntestinal Barrier Function and Reducing Inflammation. J Immunol Res. 2018 Oct 8;2018:5718396.
• Kim KY, Lee SG, Baek SY, Lee EH, Jang EJ, Lee JH, Ahn SC, Chang JH, Oh TW, Kim SH, Ma JY, Kim SC, Park KI, Kim YW. Salinomycin ameliorates oxidative hepatic damage through AMP-activated protein kinase, facilitating autophagy.Toxicol Appl Pharmacol. 2018 Dec 1;360:141-149.
• Kim KY, Park KI, Lee SG, Baek SY, Lee EH, Kim SC, Kim SH, Park SG, Yu SN, Oh TW, Kim JH, Kim KJ, Ahn SC, Kim YW. Deoxypodophyllotoxin in Anthriscus sylvestris alleviates fat accumulation in the liver via AMP-activated proteinkinase, impeding SREBP-1c signal. Chem Biol Interact. 2018 Oct 1;294:151-157.
• Kim KY, Oh TW, Ma JY, Park KI. Ethanol Extract of Lycopus lucidus Turcz. ex Benth Inhibits Metastasis by Downregulation of Runx-2 in Mouse Colon Cancer Cells. Evid Based Complement Alternat Med. 2018 Jul 19;2018:9513290.
• Yang JH, Lee E, Lee B, Cho WK, Ma JY, Park KI. Ethanolic Extracts of Artemisia apiacea Hance Improved Atopic Dermatitis-Like Skin Lesions In Vivo and Suppressed TNF-Alpha/IFN-Gamma⁻Induced Proinflammatory Chemokine Production InVitro. Nutrients. 2018 Jun 22;10(7).
• Yang JH, Do HJ, Lee E, Yim NH, Cho WK, Park KI, Ma JY. Jageum-Jung improves 2,4-dinitrochlorobenzene-induced atopic dermatitis-like skin lesions in mice and suppresses pro-inflammatory chemokine production by inhibitingTNF-α/IFN-γ-induced STAT-1 and NFκB signaling in HaCaT cells. J Ethnopharmacol. 2018 Jul 15;221:48-55.
• Oh TW, Do HJ, Kim KY, Park KI, Ma JY. Leaves of Acer palmatum thumb. Rescues N-ethyl-N-nitrosourea (ENU)-Induced retinal degeneration in mice. Phytomedicine. 2018 Mar 15;42:51-55.
• Lee MR, Park KI, Ma JY JLeonurus japonicus Houtt Attenuates Nonalcoholic Fatty Liver Disease in Free Fatty Acid-Induced HepG2 Cells and Mice Fed a High-Fat Diet. Nutrients. 2017 Dec 25;10(1).
• Park KI, Lee MR, Oh TW, Kim KY, Ma JY. Antibacterial activity and effects of Colla corii asini on Salmonella typhimurium invasion in vitro and in vivo. BMC Complement Altern Med. 2017 Dec 4;17(1):520.
• Do HJ, Oh TW, Yang JH, Park KI, Ma JY. Davallia mariesii Moore Improves FcεRI-Mediated Allergic Responses in the Rat Basophilic Leukemia Mast Cell Line RBL-2H3 and Passive Cutaneous Anaphylaxis in Mice. Mediators Inflamm.2017;2017:8701650.
• Yang JH, Yoo JM, Lee E, Lee B, Cho WK, Park KI, Yeul Ma J. Anti-inflammatory effects of Perillae Herba ethanolic extract against TNF-α/IFN-γ-stimulated human keratinocyte HaCaT cells. J Ethnopharmacol. 2018 Jan 30;211:217-223.
• Kim DG, Lee MR, Yoo JM, Park KI, Ma JY. Fermented herbal formula KIOM-MA-128 protects against acute colitis induced by dextran sodium sulfate in mice. BMC Complement Altern Med. 2017 Jul 5;17(1):354.
• Kim KY, Park KI, Kim SH, Yu SN, Park SG, Kim YW, Seo YK, Ma JY, Ahn SC. Inhibition of Autophagy Promotes Salinomycin-Induced Apoptosis via Reactive Oxygen Species-Mediated PI3K/AKT/mTOR and ERK/p38 MAPK-Dependent Signaling inHuman Prostate Cancer Cells. Int J Mol Sci. 2017 May 18;18(5).
• Kim KY, Park KI, Kim SH, Yu SN, Lee D, Kim YW, Noh KT, Ma JY, Seo YK, Ahn SC. Salinomycin Induces Reactive Oxygen Species and Apoptosis in Aggressive Breast Cancer Cells as Mediated with Regulation of Autophagy. Anticancer Res.2017 Apr;37(4):1747-1758.
• Park KI, Kim DG, Lee BH, Ma JY. Fermented Herbal Formulas KIOM-MA128 Ameliorate IL-6-Induced Intestinal Barrier Dysfunction in Colon Cancer Cell Line. Mediators Inflamm. 2016;2016:6189590.
• Park KI, Kim DG, Yoo JM, Ma JY. The Herbal Medicine KIOM-MA128 Inhibits the Antigen/IgE-Mediated Allergic Response in Vitro and in Vivo. Molecules. 2016 Aug 4;21(8).
• Kim DG, Lee MR, Yoo JM, Park KI, Ma JY. Fermented herbal formula KIOM-MA-128 protects against acute colitis induced by dextran sodium sulfate in mice. BMC Complement Altern Med. 2017 Jul 5;17(1):354.