수의과대학 수의과대학

수의해부발생학

연구내용

• 천연물추출물 및 단일화합물을 이용한 대사성질환 억제 기작 연구
• 천연물추출물을 이용하여 피부질환 개선, 탈모방지 및 발모개선 기작 연구
• 천연물 발효를 통한 생리활성 물질 및 고기능성 웰니스 소재 개발

대사성질환억제 연구의 필요성

• 닐슨리서치
  • 2015년에 발간한 '건강과 웰빙에 관한 글로벌 소비자 인식 보고서' - 한국인 5명 중 3명(60%)이 과체중이라 여기고 있고, 응답자 절반 이상(55%)이 다이어트중임.
• 마켓 앤 마켓
  • 세계 다이어트 시장규모는 2014년 기준 634조 7870억원으로 최근 5년동안 연 평균 10.9%씩 성장.국내 다이어트 시장 규모는 약 2조원으로 추정.
    
• 효과적이고 부작용이 없는 천연물을 통한 고도 비만치료제 개발 및 글로벌사업화를 통하여 바이오 의약품산업을 신성장 동력으로 만들 수 있는 가능성 큼

항비만치료제 개발의 중요성

• 현재 시판되고 있는 식욕억제제, 지방흡수억제제, 열대사증가제 및 호로몬조절제의 부작용(심장병, 고혈압, 구토, 변비, 불면증, 방귀, 지방변 등)
  • 최근 향정신성 비만 치료제에 의한 의존성 및 심각한 우울증 증가 → 보건 의학적인 측면의 부작용이 없는 비만치료제 개발 및 산업화의 필요성
    

대사성질환 억제 기작 연구

• 실험 및 연구 개발 소재
  
• 실험 및 분석 결과
  

교수 소개

학력 사항

• 동경대학교 대학원 응용동물과학전공 (박사)
• 동경대학교 대학원 응용동물과학전공 (석사)
• 경상대학교 수의학과 (학사)

경력 사항

• 경상대학교 수의과대학 수예과장
• 경상대학교 산학협력단 연구부단장
• 경상대학교 수의학과, 조교수, 부교수, 교수
• Harvard University, Massachusetts General Hospital, Research Fellow
• University of Alabama at Birmingham (UAB), Medical School, Post-doc Fellow

주요 연구업적(논문 등)

• Cho HH, Lee SJ, Kim SH, Kim TH, Cho JH. Acer tegmentosum Maxim Inhibits Adipogenesis in 3t3-l1 Adipocytes and Attenuates Lipid Accumulation in Obese Rats Fed a High-Fat Diet. Nutrients. 2020,12,3753.
• C Jeong GH. Cho JH, Jo C, Park S, Kim SB, Kim TH. Novel Hybrid Molecules Based on ()-Epigallocatechin Gallate as Potent Anti-adipogenic Agents. Chem. Pharm. Bull. 2020(68),1155–1162.
• C Lee MK, Lee HC, Cho JH, Hong IH. Thymic Hematoma Found in a Wild Eurasian Otter (Lutra lutra). Journal of Wildlife Diseases. 2020,56(4),950–952.
• CCho HH, Jang SH, Won CK, Kim HD, Kim TH, Cho JH, Rotenoisin A is a novel anti-adipogenic compound. Bioorganic & Medicinal Chemistry Letters. 2019(29),89–96.
• CJeong GH, Cho JH, Kim TH. A new approach to procyanidins synthesis with potent anti-adipogenic effects. Bioorganic & Medicinal Chemistry Letters. 2019(29),2079–2084.
• C Jeong GH, Cho JH, Bai HW, Chung BY, Kim TH. Gamma irradiation-assisted degradation of rosmarinic acid and evaluation of structures and anti-adipogenic properties. Food Chemistry. 2018(258),181–188.
• CBartley S, Cho HH, Cho JH, and Kim HD. Envisioning Molecular Network of Obesity by Omics Stratification. Journal of Nutrition and Health Sciences. 2018,5,2.
• CCho JH, Heroux E, Musa A, Kim HD. How to Visualize Depth of Interface Between Risky and Safety in the Food-Driven Intoxication? Food & Nutrition Journal. 2018,1,3.
• CSong Y, Lee SJ, Jang SH, Kim TH, Jae-Hyeon Cho. Annual Wormwood Leaf Inhibits the Adipogenesis of 3T3-L1 and Obesity in High-Fat Diet-Induced Obese Rats. Nutrients. 2017,9,554.
• CJeong GH, Cho JH, Kim SH, Kim TH. Plasma-induced dimerization of phloridzin as a new class of anti-adipogenic agents. Bioorganic & Medicinal Chemistry Letters. 2017(27),4889–4892.
• CSong Y, Kim HD, Lee MK, Hong IH, Won CK, Bai HW, Lee SS, Lee S, Chung BY, Cho JH. Maysin and Its Flavonoid Derivative from Centipedegrass Attenuates Amyloid Plaques by Inducting Humoral Immune Response with Th2 Skewed Cytokine Response in the Tg (APPswe, PS1dE9) Alzheimer's Mouse Model. PLOS ONE. 2017,10,0169509.
• CKim M, Lee S, Cho JH, Kim G, Won CK. Dopamine D3 receptor-modulated neuroprotective effects of lisuride. Neuropharmacology. 2017(117),14e20.
• CJung MS, Lee SJ, Song Y, Min W, Won C, Cho JH. Rubus crataegifolius Bunge regulates adipogenesis through Akt and inhibits high-fat diet-induced obesity in rats. Nutrition & Metabolism. 2016,13:29.
• CKim HD, Naiyeam K, Cho JH, Heck DE. Omic Paradigms Enhance Interface between Periodontitis Pathogenesis and Metabolic Disorder. Ann Obes Disord. 2016(1),3.
• CKim T, Jo C, Kim HS, Cho JH, Kim TH. Chemical constituents from Ainsliaea acerifolia as potential anti-obesity agents. Phytochemistry Letters. 2016(16),146–151.
• CKim HD, Warner S, Singh K, Cho JH, Heck DE. OMICS as Therapeutic Platform: Environmental Factors to Parkinson’s Disease. Journal of Microbial & Biochemical Technology. 2016,8:3.
• CKim MK, Park HS, Cho JH, Kim GS, Won CK. Pramipexole protects dopaminergic neurons through paraplegin against 6-hydroxydopamine. NeuroReport. 2015,26:74–80.
• CSong Y, Kim HD, Lee MK, Kang SN, Chung BY, Cho JH. Protective effect of centipedegrass against Ab oligomerization and Ab-mediated cell death in PC12 cells. Pharm Biol. 2015,53(9),1260–1266.
• CPark HJ, Lee SJ, Song Y, Jang SH, Ko YG, Kim GS, Cho JH. Schisandra chinensis Prevents Alcohol-Induced Fatty Liver Disease in Rats. J Med Food. 2014,17(1),103–110.
• CPark H, Lee HJ, Cho JH, Kim GS. Korean Scutellaria baicalensis Georgi methanol extracts inhibits metastasis via the Forkhead BoxM1 activity in hepatocellular carcinoma cells. Journal of Ethnopharmacology. 2014(155),847–851.
• CSong Y, Lee SJ, Ha JH, Ko YG, Kim HD, Min W, Kang SN, Cho JH. Sasa borealis Stem Extract Attenuates Hepatic Steatosis in High-Fat Diet-induced Obese Rats. Nutrients. 2014,6,2179-2195.
• CKang SN, Lee JS, Cho JH, Cho KK, Lee OH, Kim IS. In Vitro Anti-Osteoporosis Properties of Diverse Korean Drynariae rhizoma Phenolic Extracts. Nutrients. 2014,6,1737-1751.
• CYumnam S, Kim MK, Nagappan A, Hong GE, Lee WS, Cho JH, Kim GS. Hesperidin Induces Paraptosis Like Cell Death in Hepatoblatoma, HepG2 Cells: Involvement of ERK1/2 MAPK. Plos One. 2014,9,e101321.
• CPark HJ, Yun J, Kang SN, Ko YG, Kim HD, Cho JH. Coprinus comatus Cap Inhibits Adipocyte Differentiation via Regulation of PPARc and Akt Signaling Pathway. PLOS ONE. 2014,9(9),e105809.
• CKo YG, Park HJ, Tanaka S, Shiota k, Cho JH. Dynamic Methylation Pattern of the Methyltransferase1o (Dnmt1o) 50-Flanking Region During Mouse Oogenesis and Spermatogenesis. Molecular Reproduction & Development. 2013,80:212–222.
• CSong Y, Park HJ, Kang SN, SLee SJ, Ko YG, Kim GS, Cho JH. Blueberry Peel Extracts Inhibit Adipogenesis in 3T3-L1 Cells and Reduce High-Fat Diet-Induced Obesity. PLOS ONE. 2013,8(7),e69925.
• CChu GM, Kim JH, Ha JH, Jung MS, Song Y, Cho JH, Hag RI, Lee SS, Song YM. Effects of bamboo charcoal on the growth performance, blood characteristics and noxious gas emission in fattening pigs. Journal of Applied Animal Research. Journal of Applied Animal Research, 2013,41(1),4855.
• CKang SM, Goo YM, Cho JH, Kim IS, Lee OK. Antioxidant and Antimicrobial Activities of Ethanol Extract from the Stem and Leaf of Impatiens balsamina L.(Balsaminaceae) at Different Harvest Times. Molecules. 2013,18.
• CPark MR, Kim SW, Hwang S, Park J, Do YJ, Yang BS, Cho JH, Ko YG. Aberrant gene expression patterns in extraembryonic tissue from cloned porcine embryos. Research in Veterinary Science. 2013(94),531–538.
• CChu GM, Jung CK, Kim HY, Jung MS, Lee SJ, Song Y, Cho JH, Lee SS, Song YM. Effects of bamboo charcoal and bamboo vinegar as antibiotic alternatives on growth performance, immune responses and fecal microflora population in fattening pigs. Animal Science Journal. 2013(84),113–120.
• CPark HJ, Kim MK, Min W, Ko YG, Kim CH, Won CK, Cho JH. Citrus aurantium flavonoids inhibit adipogenesis through the Akt signaling pathway in 3T3-L1 cells. BMC Complementary and Alternative Medicine. 2012,12:31.
• CPark HJ, Cho JY, Kim MK, Phil-Ok Koh PO, Cho KW, Chung BY, Cho JH. Anti-obesity effect of Schisandra chinensis in 3T3-L1 cells and high fat diet-induced obese rats. Food Chemistry. 2012(134),227–234.